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, NetSupport Manager 11 Full crack cnnection key. NetSupport Manager Free of cost License Key Free Full Crack.Carrier proteins are substances introduced into the blood or other fluids of the body as a means of effecting a transport or inactivation of various substances in the blood. Carrier proteins are generally used to effect a more efficient delivery of a pharmaceutical agent to the body and to avoid non-specific interactions of the agent with other tissues. Further, proteins such as lactoferrin act in a host defense and antimicrobial nature, and are therefore beneficial to the patient as they limit the action of pathogenic agents.
For example, lactoferrin is an iron binding protein that sequesters iron and transports it out of the body to prevent its use by potentially pathogenic microorganisms. Lactoferrin also interferes with the growth of infectious microbes by sequestering iron, which is needed for growth. Unfortunately, the presence of lactoferrin can also interfere with the effectiveness of antibodies and therapeutic agents (e.g., antibodies, etc.).
Much research has been devoted to developing methods of preventing such interference of lactoferrin with the uptake and efficacy of therapeutic agents. A number of approaches for removing lactoferrin from blood have been developed. For example, U.S. Pat. No. 6,113,948 discloses a polyclonal antibody directed against lactoferrin which is covalently bound to solid support. Other approaches involve covalently bonding lactoferrin to a protein that does not interfere with the uptake of therapeutic agents and the like. For example, U.S. Pat. No. 6,090,416 discloses an Fc-fused protein having the ability to bind to lactoferrin and bind other complement proteins. The fusion protein is used in the treatment of agglomeration of blood platelets.
Unfortunately, the removal of lactoferrin from a body fluid generally requires large amounts of enzyme, for example, immobilized lactoferrin. Consequently, the process becomes costly and cumbersome to conduct.
An alternative approach to the removal of lactoferrin from fluids such as blood involves administering lactoferrin that is modified by linking a polyvalent ligand to the protein. The modification of the protein can include the use of an antibody or enzyme. Polyvalent ligands include biological macromolecules such as antibodies, histocompatibility antigens, enzymes and hormones that are capable
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