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The development of therapies directed to the immune system has entered a new era with the availability of new immunomodulatory agents. This review discusses the most important of these therapies and focuses on the studies that may provide the most insight for the future use of immunotherapy in breast cancer. A literature search was performed using MEDLINE, to identify key articles from the peer-reviewed literature on the use of new adjuvant therapies in breast cancer. Although progress has been made in the treatment of breast cancer, metastatic disease is still a significant problem, for which there is no cure. Adjuvant chemotherapy and local-regional radiation therapy have a major impact on treatment outcomes in breast cancer; however, these therapies are associated with significant toxicities, and it is still not entirely clear if they are cost-effective. Current chemotherapeutic agents are associated with an unacceptable frequency of systemic toxicity, and the future of adjuvant chemotherapy for breast cancer relies heavily on the development of more effective agents. Immunotherapy is a promising alternative approach to control residual disease, which will reduce the need for more cytotoxic chemotherapy in these patients. The most promising targets for immunotherapy are tumor-associated antigens (TAA), which are either expressed by tumor cells or by tumor-infiltrating leukocytes. Such targets appear to be expressed by a significant proportion of breast cancers, and thus have the potential to limit relapse and the metastatic spread of disease. All new therapeutic approaches in breast cancer, including immunotherapy, are not equal in terms of their efficacy and clinical benefits. The treatment of choice for patients with a good response to primary therapy remains single-agent paclitaxel. New approaches to adjuvant therapy will have a greater impact on overall survival in the future, and these are likely to be more targeted therapies than those currently under development.The present invention relates to a functional display apparatus for incorporating in an electronic wrist watch or the like and a method of adjusting the displaying position of such apparatus.
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