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The current challenges of effective treatment of patients with nodal and extra nodal lymphomas are discussed in terms of relevance to the current patient and tumour profile. The biology of the lymphoma and the effectiveness of existing treatments are reviewed. Recent developments in the diagnosis of nodal lymphomas and early stage extranodal lymphomas are discussed. The biology of low grade follicle centre lymphomas is reviewed in the context of the oncogene driven B cell helper T cell models and their role in tumour progression. The contribution of the B cell receptor signalling pathway to activation and viability of follicular B cells and their role in tumour biology are discussed. Early stage extranodal lymphomas can be effectively treated. Immunophenotyping and polymerase chain reaction techniques can be used to aid in the diagnosis of patients with unclassifiable lymphomas and as a tool for early response assessment. Gene expression profiling allows stratification of lymphomas into high- and low-risk groups. These techniques can be used to aid in risk stratification and to choose appropriate treatments for individual patients. Early detection of extranodal lymphomas and improved response assessment is key for successful treatment.Renal effects of elevated levels of glucagon and insulin in chronic hemodialysis patients.
Renal hemodynamic and metabolic effects of intravenous infusion of glucagon and insulin were measured in five chronic hemodialysis patients. Glucagon and insulin infusions into the left cardiac ventricle were preceded by equilibration for 2 to 3 hours with 100 mU/m2/min of human insulin and 500 micrograms/m2/min of glucagon. Measurements were obtained at baseline and after an additional 10 minutes with the continuous glucagon or insulin infusions. In all patients, glucagon decreased renal vascular resistance without affecting the glomerular filtration rate or renal plasma flow. Conversely, insulin increased all three parameters. Changes in cardiac output were correlated with those in renal
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